MedeA 2.22 includes: Updated versions of compute engines VASP, GIBBS, LAMMPS, GAUSSIAN, and MOPAC, accelerating performance and providing many new properties and features Builder capability extensions – enhancing model construction and accelerating simulation studies Updates to the MedeA Forcefield library with many new parameter sets and extensions broadening coverage and improving simulation accuracy for many materials Database updates and enhancements providing access to the latest in materials science information The release of MedeA 2.22 allows the user to: Benefit from using updated versions of all the MedeA environment compute engines, with many new features and incorporating improvements in computing performance. VASP 5.4.4 automated protocols provide response functions including electron-hole excitonic effects, accurate correlation energies from the random phase approximation, as well as new metaGGA and van der Waals functionals, efficiently and straightforwardly delivering advanced calculations. GIBBS 9.6.2 handles flexible multi-cyclic molecules opening new perspectives in property prediction for compounds of interest to a broad range of industries. MedeA-UNCLE cluster-expansion engine extends the predictive power and accuracy of ab-initio methods to efficient large scale modeling of disordered systems, and now enables simulations for multi component alloys and surfaces, permitting the study of high-entropy alloys, surface segregation and surface coverage of adsorbents. Efficiently build complex models, with the extension of the capabilities of the Thermoset Builder to allow control over relative probabilities of crosslink formation at sites capable of reacting multiple times and improve creation of large numbers of thermosets using Flowcharts and High-Throughput features. Increased simulation coverage and accuracy from the addition of new types of forcefields for molecular dynamics (ReaXFF, MEAM, Rebo) and the extensions to existing forcefields for molecular dynamics and Monte Carlo (pcff+, TraPPE-UA+, mie).